Overexpression of proteins cause chemotherapy resistance

Overexpression of the proteins 14-3-3 may be one of the causes of chemotherapy resistance, according to a new study.

Dr Julian Ceron and Dr Simo Schwartz claim that the germ line functions of par-5, one of the two 14-3-3 proteins, can make tumours resistant to treatment.

Par-5 controls DNA damage response in the body and prevents the accumulation of no-cause DNA damage and genome instability.

Its ability to repair the damage caused by chemotherapy goes into overdrive when overexpressed and protects tumours.

The discovery, while based on a worm model, has implications for clinical practice if confirmed and could lead to new treatments that prevent overexpression of proteins.

One such treatment may be CDK-1 phosphorylation, which is known to stop cell cycles and could block par-5.

The discovery follows the release of findings from a study at the University of Hull, which claimed that the prevalence of a certain family of proteins could be used as a biomarker to predict chemotherapy resistance in breast cancer patients.

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